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closely mimicking the endogenous Man6P glycan tag that directs newly synthesized lysosomal hydrolases to the lysosome
O-glycosylation (α-GalNAc) at Thr131
Ashwell-Morell receptor)
/ β-D-LacNAc-Butyl-Carboxylic Acid / β-LacNAc-C4-COOH
C21H36N2O14 / 540
PE131020: β-GalNAc-PEG3-DBCO Pack Size:2.5 mg closely mimicking the endogenous Man6PC33H41N3O10 639. 69 A D N acetylgalactosamine (GalNAc) ligand equipped with a dibenzocyclooctyne (DBCO) handle through a hydrophilic PEG3 spacer. The DBCO group reacts with azides via copper free strain promoted azide alkyne cycloaddition (SPAAC), forming stable 1,2,3 triazole linkages without a copper catalyst. This compound enables the construction of hepatocyte targeted therapeutics and research tools that exploit the asialoglycoprotein receptor
